作者
Ivana Horvat, Ana Boban, Renata Zadro, Margareta Radic Antolic, Ranka Serventi-Seiwerth, Pavle Roncevic, Ivo Radman, Dubravka Sertic, Marijo Vodanovic, Drazen Pulanic, Sandra Basic-Kinda, Nadira Durakovic, Silva Zupancic-Salek, Radovan Vrhovac, Igor Aurer, Damir Nemet, Boris Labar
发表日期
2019/1/1
期刊
Clinical Lymphoma Myeloma and Leukemia
卷号
19
期号
1
页码范围
53-63
出版商
Elsevier
简介
Introduction
Thrombosis is the most common complication in Philadelphia chromosome negative (Ph−) myeloproliferative neoplasms patients.
Patients and Methods
In a cohort of 258 Ph− myeloproliferative neoplasm patients, the difference between patients with and without thrombosis was analyzed according to genetic thrombophilia factors, JAK2 V617F status and burden allele, blood count, cardiovascular risk factors and age. Patients were also divided in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) subgroups as well as by the type of thrombosis.
Results
Analysis of cardiovascular risk factors regarding arterial thrombosis showed that PV patients with thrombosis had higher incidence of diabetes (P = .030), ET patients more often had hypertension (P = .003) and hyperlipidemia (P = .005), while PMF patients had hyperlipidemia (P = .046) and at least one cardiovascular …
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I Horvat, A Boban, R Zadro, MR Antolic… - Clinical Lymphoma Myeloma and Leukemia, 2019
