作者
Rachelle E Irwin, Sara-Jayne Thursby, Miroslava Ondičová, Kristina Pentieva, Helene McNulty, Rebecca C Richmond, Aoife Caffrey, Diane J Lees-Murdock, Marian McLaughlin, Tony Cassidy, Matthew Suderman, Caroline L Relton, Colum P Walsh
发表日期
2019/12
期刊
Clinical Epigenetics
卷号
11
页码范围
1-16
出版商
BioMed Central
简介
Background
Maternal blood folate concentrations during pregnancy have been previously linked with DNA methylation patterns, but this has been done predominantly through observational studies. We showed recently in an epigenetic analysis of the first randomized controlled trial (RCT) of folic acid supplementation specifically in the second and third trimesters (the EpiFASSTT trial) that methylation at some imprinted genes was altered in cord blood samples in response to treatment. Here, we report on epigenome-wide screening using the Illumina EPIC array (~ 850,000 sites) in these same samples (n = 86).
Results
The top-ranked differentially methylated promoter region (DMR) showed a gain in methylation with folic acid (FA) and was located upstream of the imprint regulator ZFP57. Differences in methylation in cord blood between placebo and …
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RE Irwin, SJ Thursby, M Ondičová, K Pentieva… - Clinical Epigenetics, 2019