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Aims We plan to investigate whether intraoperative cerebral desaturation in adult surgical patients requiring OLV predicts poor post-operative recovery.

Methods Thirty patients have been prospectively recruited into this observational study to date. Subjects were eligible if their procedure required a minimum duration of 45 minutes of OLV and were considered exposed if they experienced intraoperative desaturations below 65% for a minimum of three minutes. Subjects’ recovery were assessed utilizing a validated tool, the Post-Operative Quality of Recovery Scale (PQRS) which assesses six domains (physiologic, nociceptive, emotive, activities of daily living, cognitive and overall patient experience). Baselines were obtained on subjects prior to surgery and recovery was assessed each day during hospitalization. In addition, subjects were assessed daily for delirium via an expanded and validated version of the Cognitive Assessment Method (CAM). The Thoracoscore, a validated risk model for death in thoracic surgery patients, was used in analysis to adjust for co-morbidities as the score incorporates age, gender, ASA Classification, Zubrod score, type of surgery, malignancy diagnosis and several past medical history co-morbidities.

Results There was no significant difference between exposed versus unexposed groups in baseline characteristics: gender, race, primary language, history of HTN, cerebrovascular disease, COPD, diabetes or smoking. There was also no evidence of a significant difference in Thoracoscore between those patients that desaturated and those that did not.