作者
Nathan H Raines, Matthew D Cheung, Landon S Wilson, Jeffrey C Edberg, Nathaniel B Erdmann, Alec A Schmaier, Taylor F Berryhill, Zachary Manickas-Hill, Jonathan Z Li, G Yu Xu, Anupam Agarwal, Stephen Barnes, Samir M Parikh
发表日期
2021/12/1
期刊
Kidney International Reports
卷号
6
期号
12
页码范围
3002-3013
出版商
Elsevier
简介
Introduction
Acute kidney injury (AKI) is common in COVID-19 and associated with increased morbidity and mortality. We investigated alterations in the urine metabolome to test the hypothesis that impaired nicotinamide adenine dinucleotide (NAD+) biosynthesis and other deficiencies in energy metabolism in the kidney, previously characterized in ischemic, toxic, and inflammatory etiologies of AKI, will be present in COVID-19–associated AKI.
Methods
This is a case-control study among the following 2 independent populations of adults hospitalized with COVID-19: a critically ill population in Boston, Massachusetts, and a general population in Birmingham, Alabama. The cases had AKI stages 2 or 3 by Kidney Disease Improving Global Outcomes (KDIGO) criteria; the controls had no AKI. Metabolites were measured by liquid chromatography–mass spectrometry.
Results
A total of 14 cases and 14 controls were …
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