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tance vessels. DHE is a derivative of ergotamine tartrate that has been reduced at the 9-10 double bond on the D-lysergic acid moiety. Both ergotamine tartrate and DHE are agonists at the serotonin 5-HTIA, 5-HT1,, 5-HTlD, and 5-HTlF receptors, 6-* and they interact with the 5-HTz, adrenergic, and dopaminergic receptors. DHE differs from ergotamine tartrate3; although they both inhibit the reuptake of noradrenaline at sympathetic nerve endings, DHE is a less potent arterial vasoconstrictor but is almost equipotent as a venoconstrictor. DHE is a more potent alphaadrenergic blocker than ergotamine tartrate and inhibits the baroreceptor circulatory reflex. That neither drug has an effect on cerebral hemisphere blood flowl0J1 suggests that their effect in migraine is independent of any cerebrovascular vasoconstrictor properties. MoskowitzlZ showed that DHE and ergotamine tartrate block the development of …