作者
Nils Opel, Azmeraw T Amare, Ronny Redlich, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Katharina Dohm, Dario Zaremba, Elisabeth J Leehr, Joscha Böhnlein, Katharina Förster, Christian Bürger, Susanne Meinert, Verena Enneking, Daniel Emden, Ramona Leenings, Nils Winter, Tim Hahn, Walter Heindel, Jochen Bauer, David Wilhelms, Simon Schmitt, Andreas Jansen, Axel Krug, Igor Nenadic, Marcella Rietschel, Stephanie Witt, Andreas J Forstner, Markus M Nöthen, Tilo Kircher, Volker Arolt, Bernhard T Baune, Udo Dannlowski
发表日期
2020/12
期刊
Molecular Psychiatry
卷号
25
期号
12
页码范围
3422-3431
出版商
Nature Publishing Group UK
简介
Neuroticism has been shown to act as an important risk factor for major depressive disorder (MDD). Genetic and neuroimaging research has independently revealed biological correlates of neurotic personality including cortical alterations in brain regions of high relevance for affective disorders. Here we investigated the influence of a polygenic score for neuroticism (PGS) on cortical brain structure in a joint discovery sample of n = 746 healthy controls (HC) and n = 268 MDD patients. Findings were validated in an independent replication sample (n = 341 HC and n = 263 MDD). Subgroup analyses stratified for case-control status and analyses of associations between neurotic phenotype and cortical measures were carried out. PGS for neuroticism was significantly associated with a decreased cortical surface area of the inferior parietal cortex, the precuneus, the rostral cingulate cortex and the inferior frontal …
学术搜索中的文章
N Opel, AT Amare, R Redlich, J Repple, C Kaehler… - Molecular Psychiatry, 2020