作者
Ronny Redlich, Nils Opel, Christian Bürger, Katharina Dohm, Dominik Grotegerd, Katharina Förster, Dario Zaremba, Susanne Meinert, Jonathan Repple, Verena Enneking, Elisabeth Leehr, Joscha Böhnlein, Lena Winters, Neele Froböse, Sophia Thrun, Julia Emtmann, Walter Heindel, Harald Kugel, Volker Arolt, Georg Romer, Christian Postert, Udo Dannlowski
发表日期
2018/2
期刊
Neuropsychopharmacology
卷号
43
期号
3
页码范围
546-554
出版商
Nature Publishing Group
简介
Adolescent-onset major depressive disorder (MDD) is associated with an increased risk of recurrent depressive episodes, suicidal behaviors, and psychiatric morbidity throughout the lifespan. The objective of the present study was to investigate brain structural and functional changes in adolescent patients with MDD. Furthermore, we aimed to clarify the influence of early-life stress on brain function and structure. The study investigated adolescent patients with severe MDD (n= 20, mean age= 16.0, range= 15–18 years) and a control sample of matched healthy adolescents (n= 21, mean age= 16.6, range= 15–18 years). Functional MRI data were obtained using a face-matching paradigm to investigate emotion processing. Structural MRI data were analyzed using voxel-based morphometry (VBM). In line with previous studies on adult MDD, adolescent patients showed elevated amygdala activity to negative and …
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R Redlich, N Opel, C Bürger, K Dohm, D Grotegerd… - Neuropsychopharmacology, 2018