作者
Susanne Meinert, Jonathan Repple, Igor Nenadic, Axel Krug, Andreas Jansen, Dominik Grotegerd, Katharina Förster, Verena Enneking, Katharina Dohm, Simon Schmitt, Frederike Stein, Katharina Brosch, Tina Meller, Ronny Redlich, Joscha Böhnlein, Lisa Sindermann, Janik Goltermann, Elisabeth J Leehr, Nils Opel, Leni Aldermann, Andreas Reuter, Ricarda I Schubotz, Tim Hahn, Tilo Kircher, Udo Dannlowski
发表日期
2019/11
期刊
Neuropsychopharmacology
卷号
44
期号
12
页码范围
2065-2072
出版商
Springer International Publishing
简介
Reduced fractional anisotropy (FA) associated with Major Depressive Disorder (MDD) overlaps anatomically with effects of childhood maltreatment experiences. The aim of this study was, therefore, to replicate the negative effect of childhood maltreatment on white matter fiber structure and to demonstrate, that alterations in MDD might be partially attributed to the higher occurrence of childhood maltreatment in MDD. Two independent cohorts (total N = 1 256) were investigated in a diffusion tensor imaging study: The Münster Neuroimaging Cohort (MNC, N = 186 MDD, N = 210 healthy controls, HC) as discovery sample and the Marburg-Münster Affective Disorders Cohort Study (MACS, N = 397 MDD, N = 462 HC) as replication sample. The effects of diagnosis (HC vs. MDD) and Childhood Trauma Questionnaire (CTQ) scores on FA were analyzed. A main effect of diagnosis with higher FA in MDD patients …
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S Meinert, J Repple, I Nenadic, A Krug, A Jansen… - Neuropsychopharmacology, 2019