作者
Jonathan Repple, Marco Mauritz, Susanne Meinert, Siemon C de Lange, Dominik Grotegerd, Nils Opel, Ronny Redlich, Tim Hahn, Katharina Förster, Elisabeth J Leehr, Nils Winter, Janik Goltermann, Verena Enneking, Stella M Fingas, Hannah Lemke, Lena Waltemate, Igor Nenadic, Axel Krug, Katharina Brosch, Simon Schmitt, Frederike Stein, Tina Meller, Andreas Jansen, Olaf Steinsträter, Bernhard T Baune, Tilo Kircher, Udo Dannlowski, Martijn P van den Heuvel
发表日期
2020/7
期刊
Molecular psychiatry
卷号
25
期号
7
页码范围
1550-1558
出版商
Nature Publishing Group UK
简介
Major depressive disorder (MDD) is associated to affected brain wiring. Little is known whether these changes are stable over time and hence might represent a biological predisposition, or whether these are state markers of current disease severity and recovery after a depressive episode. Human white matter network (“connectome”) analysis via network science is a suitable tool to investigate the association between affected brain connectivity and MDD. This study examines structural connectome topology in 464 MDD patients (mean age: 36.6 years) and 432 healthy controls (35.6 years). MDD patients were stratified categorially by current disease status (acute vs. partial remission vs. full remission) based on DSM-IV criteria. Current symptom severity was assessed continuously via the Hamilton Depression Rating Scale (HAMD). Connectome matrices were created via a combination of T1-weighted magnetic …
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J Repple, M Mauritz, S Meinert, SC de Lange… - Molecular psychiatry, 2020