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Commonly used melanoma murine models such as B16F10 are highly aggressive but poorly immunogenic. As immunotherapies continue to demonstrate marked success in treating melanoma, a murine tumor model that elicits an effective T cell response will be more useful in investigating human responses to therapy. For this purpose, we generated an UVB-irradiated derivative of a cell line based on our BRAF V600E, CDKN2A-/-, PTEN-/-genetically engineered mouse model. This mutagenized cell line, YUMMER1. 7, was created to better resemble human melanomas, which exhibit high somatic mutation burden. Furthermore, we hypothesized that YUMMER1. 7 would induce an immune response dependent on T cell function in vivo. We find a dose-dependent growth response of YUMMER1. 7 grafted into immunocompetent C57BL/6 mice. Lower cell number injections give rise to tumors that regress after days 10 …