作者
Susan M Kaech, Scott Hemby, Ellen Kersh, Rafi Ahmed
发表日期
2002/12/13
期刊
Cell
卷号
111
期号
6
页码范围
837-851
出版商
Elsevier
简介
How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection.
引用总数
学术搜索中的文章
SM Kaech, S Hemby, E Kersh, R Ahmed - Cell, 2002