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Vancomycin is often started empirically for its reliability with gram-positive pathogens, particularly Methicillin Resistant Staph aureus (MRSA). Consequently, it is often over-prescribed. Antimicrobial stewardship programs (ASP) have used time-outs to ensure therapies are tailored to the patient with proper indication and coverage.

Between November 2022 and February 2023 provider discontinuation of IV vancomycin was prospectively reviewed when it was no longer needed at a 298 licensed bed community teaching hospital in Chicago. Results of culture sensitivities including MRSA nares screen, blood, and wound cultures were used to analyze appropriateness. Appropriateness was defined as having a positive MRSA culture, positive MRSA nares for treatment of PNA only, gram positive infections with a true and …