作者
Nathália Orlandini Costa, Lorena Ireno Borges, Liara Freitas Cavalcanti, Bruno Garcia Montagnini, Janete Aparecida Anselmo Franci, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin
发表日期
2020/4
期刊
Journal of Applied Toxicology
卷号
40
期号
4
页码范围
504-514
简介
Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8–11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post‐natal day 21 and included in the study. No litter‐mates were used for the same group. There …
引用总数
2020202120222023202425222
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