作者
Katie Hsia, Naisi Zhao, Mei Chung, Khalid Algarrahi, Laleh Montaser Kouhsari, May Fu, Hannah Chen, Siddharth Singh, Dominique S Michaud, Sushrut Jangi
发表日期
2023/10/1
期刊
Inflammatory Bowel Diseases
卷号
29
期号
10
页码范围
1613-1621
出版商
Oxford University Press
简介
Background
Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.
Methods
We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.
Results
We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by phylum Ascomycota. Compared with endoscopic remission …
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K Hsia, N Zhao, M Chung, K Algarrahi… - Inflammatory Bowel Diseases, 2023