作者
Sushrut Jangi, Hyuk Yoon, Parambir S Dulai, Mark Valasek, Brigid S Boland, Vipul Jairath, Brian G Feagan, William J Sandborn, Siddharth Singh
发表日期
2020/9
期刊
Alimentary pharmacology & therapeutics
卷号
52
期号
6
页码范围
1008-1016
简介
Background
Clinical remission is the recommended treatment target in ulcerative colitis. The predictors and outcomes of achieving histologic remission within a treat‐to‐target paradigm are not well established.
Aim
To evaluate the predictors and outcomes of achieving histologic remission in patients with ulcerative colitis treated‐to‐target of endoscopic healing (modified Mayo endoscopy score 0 or 1).
Methods
We conducted a retrospective cohort study in adults with active ulcerative colitis (modified Mayo endoscopy score 2 or 3), whose treatment was iteratively optimised to achieve endoscopic healing. We identified predictors of achieving histologic remission, and outcomes (risk of symptomatic relapse, and ulcerative colitis‐related hospitalisation and/or surgery) of achieving histologic remission vs persistent histologic activity, using Cox proportional hazard analysis.
Results
Of the 411 patients with clinically …
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S Jangi, H Yoon, PS Dulai, M Valasek, BS Boland… - Alimentary pharmacology & therapeutics, 2020