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MATERIALS AND METHODS

Animals Male albino Wistar rats (4—6 weeks old) weighing 125—150g, were obtained from animal house colony of the College of Pharmacy, King Saud University, Riyadh. All experimental procedures were conducted in accordance with the institutional guidelines for the care and use of laboratory animals and were in accordance with the local animal care and ethics committee instructions. The animals were housed in polypropylene cages in the departmental animal house under hygienic conditions in an air conditioned room controlled at 222 C, 555% humidity and with a 12-h light/dark cycle. The animals were maintained with the standard laboratory feed and water, ad libitum, throughout the period of experimentation.