作者
Rima K Dhillon-Smith, Lee J Middleton, Kirandeep K Sunner, Versha Cheed, Krys Baker, Samantha Farrell-Carver, Ruth Bender-Atik, Rina Agrawal, Kalsang Bhatia, Edmond Edi-Osagie, Tarek Ghobara, Pratima Gupta, Davor Jurkovic, Yacoub Khalaf, Marjory MacLean, Christopher McCabe, Khashia Mulbagal, Natalie Nunes, Caroline Overton, Siobhan Quenby, Raj Rai, Nick Raine-Fenning, Lynne Robinson, Jackie Ross, Andrew Sizer, Rachel Small, Alex Tan, Martyn Underwood, Mark D Kilby, Kristien Boelaert, Jane Daniels, Shakila Thangaratinam, Shiao Y Chan, Arri Coomarasamy
发表日期
2019/4/4
期刊
New England Journal of Medicine
卷号
380
期号
14
页码范围
1316-1325
出版商
Massachusetts Medical Society
简介
Background
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.
Methods
We conducted a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live-birth rates among euthyroid women who had thyroid peroxidase antibodies and a history of miscarriage or infertility. A total of 19,585 women from 49 hospitals in the United Kingdom underwent testing for thyroid peroxidase antibodies and thyroid function. We randomly assigned 952 women to receive either 50 μg once daily of levothyroxine (476 women) or placebo (476 women) before conception through the end of pregnancy. The primary outcome was live birth after at least 34 weeks of gestation.
Results
The follow-up rate for …
学术搜索中的文章
RK Dhillon-Smith, LJ Middleton, KK Sunner, V Cheed… - New England Journal of Medicine, 2019