作者
Ralph P Insinga, Gonzalo Perez, Cosette M Wheeler, Laura A Koutsky, Suzanne M Garland, Sepp Leodolter, Elmar A Joura, Daron G Ferris, Marc Steben, Darron R Brown, Elamin H Elbasha, Jorma Paavonen, Richard M Haupt
发表日期
2010/6/1
期刊
Cancer epidemiology, biomarkers & prevention
卷号
19
期号
6
页码范围
1585-1594
出版商
American Association for Cancer Research
简介
Background: We describe the incidence and duration of cervical human papillomavirus (HPV) infection episodes along with the risk of infection reappearance following a period of nondetection.
Methods: Women (1,788) ages 16 to 23 years underwent cytologic testing and PCR-based testing of cervical swab samples for HPV DNA (HPV-16/18/31/33/35/45/52/58/59) at ∼6-month intervals for up to 4 years in the context of a phase 3 clinical trial (placebo arm). HPV type–specific incidence rates were estimated per 100 person-years. Duration of type-specific cervical infection episodes and risk of reappearance following a period of nondetection were estimated using Kaplan-Meier methods.
Results: HPV-16 exhibited the highest (5.9), and HPV-35 and HPV-33 exhibited the lowest (1.0) incidence rates per 100 person-years. Mean cervical infection durations ranged from 13 months for …
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RP Insinga, G Perez, CM Wheeler, LA Koutsky… - Cancer epidemiology, biomarkers & prevention, 2010