作者
Kendra A Young, Melissa E Munroe, Joel M Guthridge, Diane L Kamen, Timothy B Niewold, Gary S Gilkeson, Michael H Weisman, Mariko L Ishimori, Jennifer Kelly, Patrick M Gaffney, Kathy H Sivils, Rufei Lu, Daniel J Wallace, David R Karp, John B Harley, Judith A James, Jill M Norris
发表日期
2017/1/1
期刊
Annals of the rheumatic diseases
卷号
76
期号
1
页码范围
153-158
出版商
BMJ Publishing Group Ltd
简介
Objective
We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE.
Methods
436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (±3.9) years later. Fifty-six individuals transitioned to SLE (≥4 cumulative American College of Rheumatology criteria). 25-Hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single-nucleotide polymorphisms in four vitamin D genes were genotyped. Generalised estimating equations, adjusting for correlation within families, were used to test associations between the vitamin D variables and the outcome of transitioning to SLE.
Results
Mean baseline 25[OH]D levels (p=0.42) and vitamin D supplementation (p=0.65) were not different between those who did and did not transition to SLE …
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KA Young, ME Munroe, JM Guthridge, DL Kamen… - Annals of the rheumatic diseases, 2017