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A simple, sensitive and specific UV spectrophotometric method was developed for the estimation of Montelukast Sodium in bulk and in tablet dosage form. The optimum conditions for the analysis of the drug were established. The wavelength maxima (λmax) for Montelukast Sodium were found to be 287.3 nm. The linearity for this method was found to be in the range of 2-100 μg/ml. The method showed high sensitivity with reproducibility in results. The calibration curve was drawn by plotting graph between absorbance and concentration. Method showed a correlation coefficient (r) of 0.999. The regression equation of the curve was y= 0.034 x+ 0.004. This sensitive method was capable to recover accurately and precisely from 80% level to 120% level of target concentration. The proposed method may be suitably applied for the analysis of Montelukast Sodium in bulk and in tablet pharmaceutical formulation for routine analysis.