作者
Cedric Manlhiot, Leonardo R Brandão, Judith Kwok, Stefan Kegel, Ines B Menjak, Caitlin L Carew, Anthony K Chan, Steven M Schwartz, V Ben Sivarajan, Christopher A Caldarone, Glen S Van Arsdell, Brian W McCrindle
发表日期
2012/9/1
期刊
The Journal of pediatrics
卷号
161
期号
3
页码范围
513-519. e3
出版商
Mosby
简介
OBJECTIVES
To describe the incidence of thrombotic complications across all 3 stages of single ventricle palliation and the association between thromboprophylaxis use and thrombotic risk.
STUDY DESIGN
Two separate cross-sectional studies were performed that included 195 patients born between 2003-2008 and 162 patients who underwent Fontan after 2000.
RESULTS
The incidence of thrombotic complications was 40% and 28% after initial palliation and superior cavopulmonary connection (SCPC), respectively; 5-year freedom from thrombotic complications after Fontan was 79%. Thromboprophylaxis was initiated for 70%, 46%, and 94% of patients after initial palliation, SCPC, and Fontan, respectively. Thromboprophylaxis with enoxaparin (vs no thromboprophylaxis) was associated with a reduction in risk of thrombotic complications after initial palliation (hazard ratio [HR] 0.5, P = .05) and SCPC (HR 0.2 …
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C Manlhiot, LR Brandão, J Kwok, S Kegel, IB Menjak… - The Journal of pediatrics, 2012