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The current study deals with the development of a glutaraldehyde cross-linked chitosan-based delivery system with improved mechanical properties utilizing the reactive solvent technique. The prepared systems were characterized by Fourier Transform Infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The systems were also analysed for mechanical and pH-dependent swelling properties and they were also analysed for their haemocompatibility and cytocompatibility. FT-IR studies indicated formation of imine bonds during the cross-linking reaction of chitosan and glutaraldehyde. TGA, XRD and mechanical studies indicated optimal properties for the system prepared with 5% methacrylic acid as reactive solvent. The developed systems indicated pH-dependent swelling behaviour with increased swelling at lower pH. The …