作者
David J Clark, Saravana M Dhanasekaran, Francesca Petralia, Jianbo Pan, Xiaoyu Song, Yingwei Hu, Felipe da Veiga Leprevost, Boris Reva, Tung-Shing M Lih, Hui-Yin Chang, Weiping Ma, Chen Huang, Christopher J Ricketts, Lijun Chen, Azra Krek, Yize Li, Dmitry Rykunov, Qing Kay Li, Lin S Chen, Umut Ozbek, Suhas Vasaikar, Yige Wu, Seungyeul Yoo, Shrabanti Chowdhury, Matthew A Wyczalkowski, Jiayi Ji, Michael Schnaubelt, Andy Kong, Sunantha Sethuraman, Dmitry M Avtonomov, Minghui Ao, Antonio Colaprico, Song Cao, Kyung-Cho Cho, Selim Kalayci, Shiyong Ma, Wenke Liu, Kelly Ruggles, Anna Calinawan, Zeynep H Gümüş, Daniel Geizler, Emily Kawaler, Guo Ci Teo, Bo Wen, Yuping Zhang, Sarah Keegan, Kai Li, Feng Chen, Nathan Edwards, Phillip M Pierorazio, Xi Steven Chen, Christian P Pavlovich, A Ari Hakimi, Gabriel Brominski, James J Hsieh, Andrzej Antczak, Tatiana Omelchenko, Jan Lubinski, Maciej Wiznerowicz, W Marston Linehan, Christopher R Kinsinger, Mathangi Thiagarajan, Emily S Boja, Mehdi Mesri, Tara Hiltke, Ana I Robles, Henry Rodriguez, Jiang Qian, David Fenyö, Bing Zhang, Li Ding, Eric Schadt, Arul M Chinnaiyan, Zhen Zhang, Gilbert S Omenn, Marcin Cieslik, Daniel W Chan, Alexey I Nesvizhskii, Pei Wang, Hui Zhang, Clinical Proteomic Tumor Analysis Consortium
发表日期
2019/10/31
期刊
Cell
卷号
179
期号
4
页码范围
964-983. e31
出版商
Cell Press
简介
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic measurements uniquely identified protein dysregulation of cellular mechanisms impacted by genomic alterations, including oxidative phosphorylation-related metabolism, protein translation processes, and phospho-signaling modules. To assess the degree of immune infiltration in individual tumors, we identified microenvironment cell signatures that delineated four immune-based ccRCC subtypes characterized by distinct cellular pathways. This study reports a large-scale proteogenomic analysis of …
学术搜索中的文章
DJ Clark, SM Dhanasekaran, F Petralia, J Pan, X Song… - Cell, 2019