作者
Alessandro Nobili, Giuseppe Licata, Francesco Salerno, Luca Pasina, Mauro Tettamanti, Carlotta Franchi, Luigi De Vittorio, Alessandra Marengoni, Salvatore Corrao, Alfonso Iorio, Maura Marcucci, Pier Mannuccio Mannucci, SIMI Investigators
发表日期
2011/5
期刊
European journal of clinical pharmacology
卷号
67
页码范围
507-519
出版商
Springer-Verlag
简介
Purposes
We evaluated the prevalence and factors associated with polypharmacy and investigated the role of polypharmacy as a predictor of length of hospital stay and in-hospital mortality.
Methods
Thirty-eight internal medicine wards in Italy participated in the Registro Politerapie SIMI (REPOSI) study during 2008. One thousand three hundred and thirty-two in-patients aged ≥65 years were enrolled. Polypharmacy was defined as the concomitant use of five or more medications. Linear regression analyses were used to evaluate predictors of length of hospital stay and logistic regression models for predictors of in-hospital mortality. Age, sex, Charlson comorbidity index, polypharmacy, and number of in-hospital clinical adverse events (AEs) were used as possible confounders.
Results
The prevalence of polypharmacy …
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A Nobili, G Licata, F Salerno, L Pasina, M Tettamanti… - European journal of clinical pharmacology, 2011