作者
Søren L Kristensen, David Preiss, Pardeep S Jhund, Iain Squire, José Silva Cardoso, Bela Merkely, Felipe Martinez, Randall C Starling, Akshay S Desai, Martin P Lefkowitz, Adel R Rizkala, Jean L Rouleau, Victor C Shi, Scott D Solomon, Karl Swedberg, Michael R Zile, John JV McMurray, Milton Packer
发表日期
2016/1
期刊
Circulation: Heart Failure
卷号
9
期号
1
页码范围
e002560
出版商
Lippincott Williams & Wilkins
简介
Background
The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial.
Methods and Results
We examined clinical outcomes in 8399 patients with heart failure and reduced ejection fraction according to history of diabetes mellitus and glycemic status (baseline hemoglobin A1c [HbA1c]: <6.0% [<42 mmol/mol], 6.0%–6.4% [42–47 mmol/mol; pre–diabetes mellitus], and ≥6.5% [≥48 mmol/mol; diabetes mellitus]), in Cox regression models adjusted for known predictors of poor outcome. Patients with a history of diabetes mellitus (n=2907 [35%]) had a higher risk of the primary composite outcome of heart failure hospitalization or cardiovascular mortality compared with those …
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SL Kristensen, D Preiss, PS Jhund, I Squire… - Circulation: Heart Failure, 2016