作者
Timo D Müller, Rubén Nogueiras, Mark L Andermann, Zane B Andrews, Stefan D Anker, Jesús Argente, Rachel L Batterham, SC Benoit, Cyril Y Bowers, Fabio Broglio, Felipe F Casanueva, D D'alessio, Inge Depoortere, Allan Geliebter, Ezio Ghigo, Philip A Cole, M Cowley, David E Cummings, Alain Dagher, Sabrina Diano, Suzanne L Dickson, Carlos Dieguez, Riccarda Granata, Harvey J Grill, K Grove, Kirk M Habegger, Kristy Heppner, Mark L Heiman, L Holsen, Birgitte Holst, Akio Inui, John-Olov Jansson, Henriette Kirchner, Marta Korbonits, Blandine Laferrere, Carel W LeRoux, Miguel Lopez, Silke Morin, Masamitsu Nakazato, R Nass, Diego Perez-Tilve, Paul T Pfluger, Thue W Schwartz, Randy J Seeley, Mark Sleeman, Yuxiang Sun, L Sussel, Jenny Tong, Michael O Thorner, Aart-Jan van der Lely, Lex HT Van der Ploeg, Jeffrey M Zigman, Masayasu Kojima, Kenji Kangawa, Roy G Smith, T Horvath, MH Tschöp
发表日期
2015/6/1
来源
Molecular metabolism
卷号
4
期号
6
页码范围
437-460
出版商
Elsevier
简介
Background
The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.
Scope of review
In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.
Major conclusions
In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.