作者
Jiaxi Yang, Naoko Sasamoto, Ana Babic, Allison F Vitonis, Mary K Townsend, Linda Titus, Daniel W Cramer, Shelley S Tworoger, Kathryn L Terry
发表日期
2021/7/1
期刊
International journal of cancer
卷号
149
期号
1
页码范围
75-83
出版商
John Wiley & Sons, Inc.
简介
Results of studies assessing intrauterine device (IUD) use and ovarian cancer risk are inconsistent. We examined the association between IUD use, including duration, type and timing of use, and ovarian cancer risk using three population‐based studies. Data from the New England Case‐Control Study (NEC) and two prospective cohort studies, the Nurses' Health Studies (NHS/NHSII), were included in the analysis. Information on IUD use was collected by in‐person interview in NEC and by biennial questionnaire in NHS/NHSII. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) in NEC and Cox regression to calculate hazard ratios (HR) and 95% CI in NHS/NHSII. We used meta‐analysis to combine the NEC and the pooled NHS/NHSII results. Overall, IUD use was not associated with epithelial ovarian cancer risk (OR = 0.96, 95% CI: 0.81‐1.14 in NEC; HR = 0 …
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