作者
Oliver Ratmann, Ard Van Sighem, Daniela Bezemer, Alexandra Gavryushkina, Suzanne Jurriaans, Annemarie Wensing, Frank De Wolf, Peter Reiss, Christophe Fraser, ATHENA observational cohort
发表日期
2016/1/6
期刊
Science translational medicine
卷号
8
期号
320
页码范围
320ra2-320ra2
出版商
American Association for the Advancement of Science
简介
New HIV diagnoses among men having sex with men (MSM) have not decreased appreciably in most countries, even though care and prevention services have been scaled up substantially in the past 20 years. To maximize the impact of prevention strategies, it is crucial to quantify the sources of transmission at the population level. We used viral sequence and clinical patient data from one of Europe’s nationwide cohort studies to estimate probable sources of transmission for 617 recently infected MSM. Seventy-one percent of transmissions were from undiagnosed men, 6% from men who had initiated antiretroviral therapy (ART), 1% from men with no contact to care for at least 18 months, and 43% from those in their first year of infection. The lack of substantial reductions in incidence among Dutch MSM is not a result of ineffective ART provision or inadequate retention in care. In counterfactual modeling scenarios …
引用总数
2016201720182019202020212022202320241321182311161385
学术搜索中的文章