作者
Stefan Neubauer, Michael Horn, Anne Naumann, Rong Tian, Kai Hu, Martin Laser, Jan Friedrich, Peter Gaudron, K Schnackerz, JS Ingwall
发表日期
1995/3/1
期刊
The Journal of clinical investigation
卷号
95
期号
3
页码范围
1092-1100
出版商
American Society for Clinical Investigation
简介
The purpose of this study was to test the hypothesis that energy metabolism is impaired in residual intact myocardium of chronically infarcted rat heart, contributing to contractile dysfunction. Myocardial infarction (MI) was induced in rats by coronary artery ligation. Hearts were isolated 8 wk later and buffer-perfused isovolumically. MI hearts showed reduced left ventricular developed pressure, but oxygen consumption was unchanged. High-energy phosphate contents were measured chemically and by 31P-NMR spectroscopy. In residual intact left ventricular tissue, ATP was unchanged after MI, while creatine phosphate was reduced by 31%. Total creatine kinase (CK) activity was reduced by 17%, the fetal CK isoenzymes BB and MB increased, while the "adult" mitochondrial CK isoenzyme activity decreased by 44%. Total creatine content decreased by 35%. Phosphoryl exchange between ATP and creatine …
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S Neubauer, M Horn, A Naumann, R Tian, K Hu… - The Journal of clinical investigation, 1995