作者
Angelo Vacca, Domenico Ribatti, Marco Presta, Monica Minischetti, Monica Iurlaro, Roberto Ria, Adriana Albini, Federico Bussolino, Franco Dammacco
发表日期
1999/5/1
期刊
Blood, The Journal of the American Society of Hematology
卷号
93
期号
9
页码范围
3064-3073
出版商
American Society of Hematology
简介
To assess whether the progression of plasma cell tumors is accompanied by angiogenesis and secretion of matrix-degrading enzymes, bone marrow biopsy specimens from 20 patients with monoclonal gammopathy of undetermined significance (MGUS), 18 patients with nonactive multiple myeloma (MM), and 26 patients with active MM were evaluated for their angiogenic potential and matrix-metalloproteinase (MMP) production. A fivefold increase of the factor VIII+microvessel area was measured by a planimetric method of point counting in the bone marrow of patients with active MM as compared with nonactive MM and MGUS patients (P < .01). When serum-free conditioned media (CM) of plasma cells isolated from the bone marrow of each patient were tested in vivo for their angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay, the incidence of angiogenic samples was significantly …
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A Vacca, D Ribatti, M Presta, M Minischetti, M Iurlaro… - Blood, The Journal of the American Society of …, 1999