作者
Sven Sandin, Karl-Gösta Nygren, Anastasia Iliadou, Christina M Hultman, Abraham Reichenberg
发表日期
2013/7/3
期刊
Jama
卷号
310
期号
1
页码范围
75-84
出版商
American Medical Association
简介
Importance
Between 1978 and 2010, approximately 5 million infants were born after in vitro fertilization (IVF) treatments. Yet limited information on neurodevelopment after IVF exists, especially after the first year of life.
Objective
To examine the association between use of any IVF and different IVF procedures and the risk of autistic disorder and mental retardation in the offspring.
Design, Setting, and Participants
A population-based, prospective cohort study using Swedish national health registers. Offspring born between 1982 and 2007 were followed up for a clinical diagnosis of autistic disorder or mental retardation until December 31, 2009. The exposure of interest was IVF, categorized according to whether intracytoplasmic sperm injection (ICSI) for male infertility was used and whether embryos were fresh or frozen. For ICSI, whether sperm were ejaculated or surgically extracted was also considered.
Main Outcomes …
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