作者
AJ Akindele, AA Adeneye, F Olatoye, AS Benebo
发表日期
2014/8
期刊
Human & experimental toxicology
卷号
33
期号
8
页码范围
831-846
出版商
Sage Publications
简介
The ameliorative effect of calcium channel blockers (CCBs) and a phospholipase-A2 inhibitor in drug-/chemical-induced nephrotoxicity was investigated. Rats were divided into 7 groups of 5 rats in each group. In the gentamicin model, group I rats were pretreated with normal saline (10 ml kg−1), while groups II–VII rats were pretreated with normal saline (10 ml kg−1), ascorbic acid (10 mg kg−1), nifedipine (0.86 mg kg−1), verapamil (4.3 mg kg−1), diltiazem (3.43 mg kg−1), and prednisolone (0.57 mg kg−1), respectively, perorally 1 h before intraperitoneal (i.p.) injection of gentamicin (40 mg kg−1) for 14 days. In the carbon tetrachloride (CCl4) model, rats were pretreated with CCBs and prednisolone for 7 days before inducing nephrotoxicity with 20% CCl4 (1.5 ml kg−1). Rats were thereafter killed and blood and tissue samples were collected for assessments. I.p. injections of gentamicin and CCl4 caused significant …
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AJ Akindele, AA Adeneye, F Olatoye, AS Benebo - Human & experimental toxicology, 2014