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The ameliorative effect of calcium channel blockers (CCBs) and a phospholipase-A₂ inhibitor in drug-/chemical-induced nephrotoxicity was investigated. Rats were divided into 7 groups of 5 rats in each group. In the gentamicin model, group I rats were pretreated with normal saline (10 ml kg⁻¹), while groups II–VII rats were pretreated with normal saline (10 ml kg⁻¹), ascorbic acid (10 mg kg⁻¹), nifedipine (0.86 mg kg⁻¹), verapamil (4.3 mg kg⁻¹), diltiazem (3.43 mg kg⁻¹), and prednisolone (0.57 mg kg⁻¹), respectively, perorally 1 h before intraperitoneal (i.p.) injection of gentamicin (40 mg kg⁻¹) for 14 days. In the carbon tetrachloride (CCl₄) model, rats were pretreated with CCBs and prednisolone for 7 days before inducing nephrotoxicity with 20% CCl₄ (1.5 ml kg⁻¹). Rats were thereafter killed and blood and tissue samples were collected for assessments. I.p. injections of gentamicin and CCl₄ caused significant …