作者
Mi Ji Lee, Sang Won Seo, Duk L Na, Changsoo Kim, Jae Hyun Park, Geon Ha Kim, Chi Hun Kim, Young Noh, Hanna Cho, Hee Jin Kim, Cindy W Yoon, Byoung Seok Ye, Juhee Chin, Seun Jeon, Jong-Min Lee, Yearn Seong Choe, Kyung-Han Lee, Jae Seung Kim, Sung Tae Kim, Jae-Hong Lee, Michael Ewers, David J Werring, Michael W Weiner
发表日期
2014/4/1
期刊
JAMA psychiatry
卷号
71
期号
4
页码范围
412-422
出版商
American Medical Association
简介
Importance
Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of cognitive impairment in the elderly. However, few studies have evaluated the relationship between CVD and β-amyloid burden in living humans or their synergistic effects on cognition. Thus, there is a need for better understanding of mild cognitive impairment (MCI) before clinical deterioration begins.
Objective
To determine the synergistic effects of β-amyloid burden and CVD on cognition in patients with subcortical vascular MCI (svMCI).
Design, Setting, and Participants
A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We prospectively recruited 95 patients with svMCI; 67 of these individuals participated in the study. Forty-five patients with amnestic MCI (aMCI) were group matched with those with svMCI by the Clinical Dementia Rating Scale Sum of Boxes.
Main Outcomes and …
学术搜索中的文章
MJ Lee, SW Seo, DL Na, C Kim, JH Park, GH Kim… - JAMA psychiatry, 2014