作者
Azizath Moussiliou, Yolande Sissinto-Savi De Tove, Justin Doritchamou, Adrian JF Luty, Achille Massougbodji, Michael Alifrangis, Philippe Deloron, Nicaise Tuikue Ndam
发表日期
2013/12
期刊
Malaria journal
卷号
12
页码范围
1-9
出版商
BioMed Central
简介
Background
Despite widespread parasite resistance to sulphadoxine-pyrimethamine (SP) its use for intermittent preventative treatment during pregnancy remains the policy in Benin and throughout most of sub-Saharan Africa.
Methods
In a prospective study, 982 pregnant women were recruited in Benin and followed until delivery. The prevalence of point mutations in the pfdhfr and pfdhps genes associated with Plasmodium falciparum resistance to SP during consecutive antenatal visits was determined. Parasites clearance among women infected at SP intake was assessed by microscopy and PCR. Association between the persistence of parasites and malaria consequences, were investigated. Recurrent parasites were genotyped to identify recrudescences from re-infections.
Results
The prevalence of pfdhfr/pfdhps …
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A Moussiliou, YSS De Tove, J Doritchamou, AJF Luty… - Malaria journal, 2013