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In conclusion, we conducted a virtual screen of both a virtual library of commercially available drug-like molecules and the NCI library targeting the falcilysin protein of Plasmodium falciparum. Our top 34 combined computational hits were then tested for activity against both the 3D7 strain of P. falciparum and falcilysin. Eight compounds (26%) displayed good activity against 3D7, with two of the eight compounds (ZN-11 and NC-05) also showing inhibition against FLN. While these compounds are not sufficiently potent to advance, we believe they are promising lead candidates which serve as a starting point to develop new antimalarials with a unique mode of action.