作者
Thomas Van den Broeck, Roderick Cn Van Den Bergh, Nicolas Arfi, Tobias Gross, Lisa Moris, Erik Briers, Marcus Cumberbatch, Maria De Santis, Derya Tilki, Stefano Fanti, Nicola Fossati, Silke Gillessen, Jeremy P Grummet, Ann M Henry, Michael Lardas, Matthew Liew, Olivier Rouvière, Jakub Pecanka, Malcolm D Mason, Ivo G Schoots, Theo H van Der Kwast, Henk G van Der Poel, Thomas Wiegel, Peter-Paul M Willemse, Yuhong Yuan, Thomas B Lam, Philip Cornford, Nicolas Mottet
发表日期
2019/6/1
来源
European urology
卷号
75
期号
6
页码范围
967-987
出版商
Elsevier
简介
Context
In men with prostate cancer (PCa) treated with curative intent, controversy exists regarding the impact of biochemical recurrence (BCR) on oncological outcomes.
Objective
To perform a systematic review of the existing literature on BCR after treatment with curative intent for nonmetastatic PCa. Objective 1 is to investigate whether oncological outcomes differ between patients with or without BCR. Objective 2 is to study which clinical factors and tumor features in patients with BCR have an independent prognostic impact on oncological outcomes.
Evidence acquisition
Medline, Medline In-Process, Embase, and the Cochrane Central Register of Controlled Trials were searched. For objective 1, prospective and retrospective studies comparing survival outcomes of patients with or without BCR following radical prostatectomy (RP) or radical radiotherapy (RT) were included. For objective 2, all studies with at least …
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T Van den Broeck, RC Van Den Bergh, N Arfi, T Gross… - European urology, 2019