作者
Lisa Moris, Marcus G Cumberbatch, Thomas Van den Broeck, Giorgio Gandaglia, Nicola Fossati, Brian Kelly, Raj Pal, Erik Briers, Philip Cornford, Maria De Santis, Stefano Fanti, Silke Gillessen, Jeremy P Grummet, Ann M Henry, Thomas BL Lam, Michael Lardas, Matthew Liew, Malcolm D Mason, Muhammad Imran Omar, Olivier Rouvière, Ivo G Schoots, Derya Tilki, Roderick CN van den Bergh, Theodorus H van Der Kwast, Henk G van Der Poel, Peter-Paul M Willemse, Cathy Y Yuan, Badrinath Konety, Tanya Dorff, Suneil Jain, Nicolas Mottet, Thomas Wiegel
发表日期
2020/5/1
来源
European urology
卷号
77
期号
5
页码范围
614-627
出版商
Elsevier
简介
Context
The optimal treatment for men with high-risk localized or locally advanced prostate cancer (PCa) remains unknown.
Objective
To perform a systematic review of the existing literature on the effectiveness of the different primary treatment modalities for high-risk localized and locally advanced PCa. The primary oncological outcome is the development of distant metastases at ≥5 yr of follow-up. Secondary oncological outcomes are PCa-specific mortality, overall mortality, biochemical recurrence, and need for salvage treatment with ≥5 yr of follow-up. Nononcological outcomes are quality of life (QoL), functional outcomes, and treatment-related side effects reported.
Evidence acquisition
Medline, Medline In-Process, Embase, and the Cochrane Central Register of Randomized Controlled Trials were searched. All comparative (randomized and nonrandomized) studies published between January 2000 and May …
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L Moris, MG Cumberbatch, T Van den Broeck… - European urology, 2020