作者
Miles W Carroll, David A Matthews, Julian A Hiscox, Michael J Elmore, Georgios Pollakis, Andrew Rambaut, Roger Hewson, Isabel García-Dorival, Joseph Akoi Bore, Raymond Koundouno, Saïd Abdellati, Babak Afrough, John Aiyepada, Patience Akhilomen, Danny Asogun, Barry Atkinson, Marlis Badusche, Amadou Bah, Simon Bate, Jan Baumann, Dirk Becker, Beate Becker-Ziaja, Anne Bocquin, Benny Borremans, Andrew Bosworth, Jan Peter Boettcher, Angela Cannas, Fabrizio Carletti, Concetta Castilletti, Simon Clark, Francesca Colavita, Sandra Diederich, Adomeh Donatus, Sophie Duraffour, Deborah Ehichioya, Heinz Ellerbrok, Maria Dolores Fernandez-Garcia, Alexandra Fizet, Erna Fleischmann, Sophie Gryseels, Antje Hermelink, Julia Hinzmann, Ute Hopf-Guevara, Yemisi Ighodalo, Lisa Jameson, Anne Kelterbaum, Zoltan Kis, Stefan Kloth, Claudia Kohl, Miša Korva, Annette Kraus, Eeva Kuisma, Andreas Kurth, Britta Liedigk, Christopher H Logue, Anja Lüdtke, Piet Maes, James McCowen, Stéphane Mély, Marc Mertens, Silvia Meschi, Benjamin Meyer, Janine Michel, Peter Molkenthin, César Muñoz-Fontela, Doreen Muth, Edmund NC Newman, Didier Ngabo, Lisa Oestereich, Jennifer Okosun, Thomas Olokor, Racheal Omiunu, Emmanuel Omomoh, Elisa Pallasch, Bernadett Pályi, Jasmine Portmann, Thomas Pottage, Catherine Pratt, Simone Priesnitz, Serena Quartu, Julie Rappe, Johanna Repits, Martin Richter, Martin Rudolf, Andreas Sachse, Kristina Maria Schmidt, Gordian Schudt, Thomas Strecker, Ruth Thom, Stephen Thomas, Ekaete Tobin, Howard Tolley, Jochen Trautner, Tine Vermoesen, Inês Vitoriano, Matthias Wagner, Svenja Wolff, Constanze Yue, Maria Rosaria Capobianchi, Birte Kretschmer, Yper Hall, John G Kenny, Natasha Y Rickett, Gytis Dudas, Cordelia EM Coltart, Romy Kerber, Damien Steer, Callum Wright, Francis Senyah, Sakoba Keita, Patrick Drury, Boubacar Diallo, Hilde De Clerck, Michel Van Herp, Armand Sprecher, Alexis Traore, Mandiou Diakite, Mandy Kader Konde, Lamine Koivogui, N’Faly Magassouba, Tatjana Avšič-Županc, Andreas Nitsche, Marc Strasser, Giuseppe Ippolito, Stephan Becker, Kilian Stoecker, Martin Gabriel, Hervé Raoul, Antonino Di Caro, Roman Wölfel, Pierre Formenty, Stephan Günther
发表日期
2015/8/6
期刊
Nature
卷号
524
期号
7563
页码范围
97-101
出版商
Nature Publishing Group UK
简介
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded,,. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref. ). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea …
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