作者
Olwen C Murphy, Kevin Messacar, Leslie Benson, Riley Bove, Jessica L Carpenter, Thomas Crawford, Janet Dean, Roberta DeBiasi, Jay Desai, Matthew J Elrick, Raquel Farias-Moeller, Grace Y Gombolay, Benjamin Greenberg, Matthew Harmelink, Sue Hong, Sarah E Hopkins, Joyce Oleszek, Catherine Otten, Cristina L Sadowsky, Teri L Schreiner, Kiran T Thakur, Keith Van Haren, Carolina M Carballo, Pin Fee Chong, Amary Fall, Vykuntaraju K Gowda, Jelte Helfferich, Ryutaro Kira, Ming Lim, Eduardo L Lopez, Elizabeth M Wells, E Ann Yeh, Carlos A Pardo, Andrea Salazar-Camelo, Divakar Mithal, Molly Wilson-Murphy, Andrea Bauer, Colyn Watkins, Mark Abzug, Samuel Dominguez, Craig Press, Michele Yang, Nusrat Ahsan, Leigh Ramos-Platt, Emmanuelle Tiongson, Mitchel Seruya, Ann Tilton, Elana Katz, Matthew Kirschen, Apurva Shah, Erlinda Ulloa, Sabrina Yum, Lileth Mondok, Megan Blaufuss, Amy Rosenfeld, Wendy Vargas, Jason Zucker, Anusha Yeshokumar, Allison Navis, Kristen Chao, Kaitlin Hagen, Michelle Melicosta, Courtney Porter, Margaret Tunney, Richard Scheuermann, Priya Duggal, Andrew Pekosz, Amy Bayliss, Meghan Moore, Allan Belzberg, Melania Bembea, Caitlin O'Brien, Rebecca Riggs, Jessica Nance, Aaron Milstone, Jessica Rice, Maria A Garcia-Dominguez, Eoin Flanagan, Jan-Mendelt Tillema, Glendaliz Bosques, Sonal Bhatia, Eliza Gordon-Lipkin, Dawn Deike, Gadi Revivo, Dan Zlotolow, Gabrielle deFiebre, Peggy Lazerow, Timothy Lotze, Ari Bitnun, Kristen Davidge, Jiri Vajsar, Amy Moore, Chamindra Konersman, Kendall Nash, Jonathan Strober, Nalin Gupta, Charles Chiu, Michael Sweeney, William Jackson, Dennis Simon, Kavita Thakkar, Jonathan Cheng, John Luce, Suman Das, Matthew Vogt, NgocHanh Vu, Jacqueline Gofshteyn, Naila Makhani, Payal Patel
发表日期
2021/1/23
来源
The Lancet
卷号
397
期号
10271
页码范围
334-346
出版商
Elsevier
简介
Acute flaccid myelitis (AFM) is a disabling, polio-like illness mainly affecting children. Outbreaks of AFM have occurred across multiple global regions since 2012, and the disease appears to be caused by non-polio enterovirus infection, posing a major public health challenge. The clinical presentation of flaccid and often profound muscle weakness (which can invoke respiratory failure and other critical complications) can mimic several other acute neurological illnesses. There is no single sensitive and specific test for AFM, and the diagnosis relies on identification of several important clinical, neuroimaging, and cerebrospinal fluid characteristics. Following the acute phase of AFM, patients typically have substantial residual disability and unique long-term rehabilitation needs. In this Review we describe the epidemiology, clinical features, course, and outcomes of AFM to help to guide diagnosis, management, and …
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OC Murphy, K Messacar, L Benson, R Bove… - The Lancet, 2021