查看文章

To study the effect of flunixin meglumine on short circuit current (Isc) in equine right ventral colon in vitro.

Intestinal mucosa from healthy horses and ponies.

Isc was measured in mucosa from the right ventral colon mounted in Ussing chambers. In experiment 1, collection and incubation solutions were: control (no additions): flunixin meglumine, 4 μg/ml; indomethacin, 10 ^-6 M ; and flunixin meglumine (4 μg/ml) with 10 ^-6 M prostaglandin E ₂ . In experiment 2, incubation conditions were: control (plain Krebs-Ringer bicarbonate [KRB] solution); flunixin meglumine, 4 μg/ml in KRB; chloride-free buffer solution; flunixin meglumine (4 μg/ml) in a chloride-free buffer solution; and plain KRB with 10 ^-6 M prostaglandin E ₂ …