作者
Rivka Ben Ishay, Liron L Israel, Esthy Levy Eitan, David M Partouche, Jean-Paul Lellouche
发表日期
2016
期刊
Journal of Materials Chemistry B
卷号
4
期号
21
页码范围
3801-3814
出版商
Royal Society of Chemistry
简介
Human Serum Albumin (HSA) is the most abundant plasma protein in human blood, and therefore, it is the material of choice for the development of particulate formulations due to its biodegradable and biocompatible nature. Over the last decade, HSA nanoparticles (NPs) have been prepared mostly using desolvation techniques and evaluated as promising drug carriers. In addition, controlling the particle size has become a primary concern while formulating such nanoparticulate systems. Since many of these HSA-based carrier systems have often demonstrated batch-to-batch fabrication variability, significant efforts have been made to develop and characterize HSA-based NPs featuring a robust and controllable particle size, by using a desolvation/cross-linking-type Divinyl Sulfone (DVS)-mediated nanofabrication method. For this purpose and for global multi-parameter fabrication process optimization, a …
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RB Ishay, LL Israel, EL Eitan, DM Partouche… - Journal of Materials Chemistry B, 2016