作者
Olivier Boucherat, Tetsuro Yokokawa, Vinod Krishna, Shanker Kalyana-Sundaram, Sandra Martineau, Sandra Breuils-Bonnet, Nabil Azhar, Fany Bonilla, David Gutstein, François Potus, Allan Lawrie, Jey Jeyaseelan, Steeve Provencher, Sebastien Bonnet
发表日期
2022/8
期刊
Nature cardiovascular research
卷号
1
期号
8
页码范围
748-760
出版商
Nature Publishing Group UK
简介
Although right ventricular (RV) function is the primary determinant of morbidity and mortality in pulmonary arterial hypertension (PAH), the molecular mechanisms of RV remodeling and the circulating factors reflecting its function remain largely elusive. In this context, the identification of new molecular players implicated in maladaptive RV remodeling along with the optimization of risk stratification approaches in PAH are key priorities. Through combination of transcriptomic and proteomic profiling of RV tissues with plasma proteome profiling, we identified a panel of proteins, mainly related to cardiac fibrosis, similarly upregulated in the RV and plasma of patients with PAH with decompensated RV. Among these, we demonstrated that plasma latent transforming growth factor beta binding protein 2 (LTBP-2) level correlates with RV function in human PAH and adds incremental value to current risk stratification models to …
引用总数
学术搜索中的文章