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OBJECTIVE

To perform a systematic review and a meta-analysis of diagnostic accuracy of the different tests aimed to detect Helicobacter pylori infection in patients with upper gastrointestinal bleeding (UGIB).

METHODS

Selection of studies: assessing the accuracy of H. pylori diagnostic methods in patients with UGIB. Search strategy: electronic bibliographical searches. Data extraction: independently done by two reviewers. Data synthesis: meta-analyses of the different tests were performed combining the sensitivities, specificities, and likelihood ratios (LRs) of the individual studies.

RESULTS

Studies showed a high degree of heterogeneity. Pooled sensitivity, specificity, LR+ and LR–(95% confidence interval (CI)) for the different methods were: Rapid urease test (16 studies/1,417 patients): 0.67 (0.64–0.70), 0.93 (0.90–0.96), 9.6 (5.1–18.1), and 0.31 (0.22–0.44). Histology (10 studies/827 patients): 0.70 (0.66–0.74), 0 …