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The main aim of drug delivery nanosystems is to administer a drug to a precise site of action at a therapeutic concentration for a defined period. Different parameters come into play when designing a drug delivery system. One of the most noticeable parameters is the release profile which should be tuned according to the drug’s concentration at the administration time, the period at which the drug must sustain a therapeutic concentration, and the planned site of action. 1 Nanotechnology has been used massively to improve the therapeutic index and pharmacokinetic properties of a variety of drugs. 2–5 Among the different types of soft nanoparticles, nanoliposomes became well-established nanocarriers capable of efficiently encapsulating and delivering different types of drugs. 6 The main components of nanoliposomes are phospholipids, which are amphiphilic molecules containing a lipid-soluble, hydrophobic tail …