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T-box genes regulate development processes, and some of these genes also have a role in cell proliferation and survival. TBX15, as a T-box transcription factor, is required in skeletal development; in fact, the human Cousin syndrome which is characterized by many skeleton malformations is promoted by alterations in the TBX15 gene. Also, TBX15 has been associated with the differentiation of adipocyte cells. Recently, the methylation of the TBX15 promoter has been suggested as a marker in prostate cancer, but its function in carcinogenesis is unknown.