作者
Sujong Kim, Insuk Sohn, Joon-Ik Ahn, Ki-Hwan Lee, Yeon Sook Lee, Yong Sung Lee
发表日期
2004/9/29
期刊
Gene
卷号
340
期号
1
页码范围
99-109
出版商
Elsevier
简介
To understand the molecular mechanisms underlying alterations in the pathophysiologic status of dietary obesity, we examined hepatic genes differentially expressed in a long-term high-fat intake-induced obesity mouse model. C57BL/6J male mice were fed with two kinds of diets for 12 weeks; a low-fat diet (LFD), a high-fat diet (HFD; n=8), and the expression levels of ∼10,000 transcripts in liver tissues from the two groups were assessed using cDNA microarray analysis. Twelve-week feeding with the HFD resulted in significant increase in body weight, visceral fat accumulation and circulating cholesterol concentration, compared with the LFD group. The cDNA microarray analysis revealed marked differences in the expressions of 97 hepatic genes. These genes were categorized into seven groups: The expression of genes involved in fatty acid catabolism and ketone body synthesis, such as acyl–CoA oxidase1 …
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