作者
Yoo-Young Lee, Tae-Joong Kim, Ji-Young Kim, Chel Hun Choi, In-Gu Do, Sang Yong Song, Insuk Sohn, Sin-Ho Jung, Duk-Soo Bae, Jeong-Won Lee, Byoung-Gie Kim
发表日期
2013/12/1
期刊
Gynecologic oncology
卷号
131
期号
3
页码范围
650-654
出版商
Academic Press
简介
Objective
Recurrence is the major cause of death in early cervical cancer. We compared the prediction powers for disease recurrence between the gene set prognostic model and the clinical prognostic model.
Materials and methods
A gene set model to predict disease free survival was developed using the cDNA-mediated annealing, selection, extension, and ligation (DASL) assay data set from a cohort of early cervical cancer patients who had been treated with radical surgery with or without adjuvant therapy. A clinical prediction model was also developed using the same cohort, and the ability of predicting recurrence from each model was compared.
Results
Adequate DASL assay profiles were obtained from 300 patients, and we selected 12 genes for the gene set model. When patients were categorized as having a low or high risk by the prognostic score, the Kaplan–Meier curve showed significantly different …
学术搜索中的文章
YY Lee, TJ Kim, JY Kim, CH Choi, IG Do, SY Song… - Gynecologic oncology, 2013