作者
Malgorzata A Verboon‐Maciolek, Floris Groenendaal, Cecil D Hahn, Jonathan Hellmann, Anton M van Loon, Guy Boivin, Linda S de Vries
发表日期
2008/9/28
期刊
Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society
卷号
64
期号
3
页码范围
266-273
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
To assess the role of human parechoviruses (HPeVs) as a cause of neonatal cerebral infection and to report neuroimaging findings of newborn infants with encephalitis caused by HPeVs.
Methods
Clinical presentation, cranial ultrasonography, magnetic resonance imaging (MRI) findings, and neurodevelopmental outcome of 10 infants admitted to a neonatal intensive care unit and diagnosed with encephalitis caused by HPeVs are reported.
Results
Nine of 10 infants, with a gestational age of 29 to 41 weeks, presented at 36 to 41 weeks postmenstrual age with clinical seizures. Seven had a fever and six had a rash. Clinical presentation was similar to that of infants with enterovirus infection. Cranial ultrasonography showed increased echogenicity in the periventricular white matter in all infants. Neonatal MRI confirmed white matter changes in nine infants, which changed to gliosis on later MRI …
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