作者
Kim Doré, Sébastien Dubus, Hoang-Anh Ho, Isabelle Lévesque, Maryse Brunette, Geneviève Corbeil, Maurice Boissinot, Guy Boivin, Michel G Bergeron, Denis Boudreau, Mario Leclerc
发表日期
2004/4/7
期刊
Journal of the American Chemical Society
卷号
126
期号
13
页码范围
4240-4244
出版商
American Chemical Society
简介
We report the specific detection of a few hundred molecules of genetic material using a fluorescent polythiophene biosensor. Such recognition is based on simple electrostatic interactions between a cationic polymeric optical transducer and the negatively charged nucleic acid target and can be done in less than 1 h, simply and affordably, and without any chemical reaction. This simple system is versatile enough to detect nucleic acids of various lengths, including a segment from the RNA genome of the Influenza virus.
引用总数
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K Doré, S Dubus, HA Ho, I Lévesque, M Brunette… - Journal of the American Chemical Society, 2004