作者
Kaixin Zhou, Astrid Dempfle, Mauricio Arcos‐Burgos, Steven C Bakker, Tobias Banaschewski, Joseph Biederman, Jan Buitelaar, F Xavier Castellanos, Alysa Doyle, Richard P Ebstein, Jenny Ekholm, Paola Forabosco, Barbara Franke, Christine Freitag, Susann Friedel, Michael Gill, Johannes Hebebrand, Anke Hinney, Christian Jacob, Klaus Peter Lesch, Sandra K Loo, Francisco Lopera, James T McCracken, James J McGough, Jobst Meyer, Eric Mick, Ana Miranda, Maximilian Muenke1, Fernando Mulas, Stanley F Nelson, T Trang Nguyen, Robert D Oades, Matthew N Ogdie, Juan David Palacio, David Pineda, Andreas Reif, Tobias J Renner, Herbert Roeyers, Marcel Romanos, Aribert Rothenberger, Helmut Schäfer, Joseph Sergeant, Richard J Sinke, Susan L Smalley, Edmund Sonuga‐Barke, Hans‐Christoph Steinhausen, Emma Van der Meulen, Susanne Walitza, Andreas Warnke, Cathryn M Lewis, Stephen V Faraone, Philip Asherson
发表日期
2008/12/5
期刊
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
卷号
147
期号
8
页码范围
1392-1398
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel …
引用总数
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学术搜索中的文章
K Zhou, A Dempfle, M Arcos‐Burgos, SC Bakker… - American Journal of Medical Genetics Part B …, 2008